Silver Nanoclusters Decrease Bacterial Resistance to Heavy Metals and Antibiotics.

ABSTRACT: Nanomaterials are widely used in biomedical research as drug and antibody carriers, and some nanomaterials have been shown to exhibit antimicrobial activity. Previously, silver nanoclusters (AgNCs) were predicted to interact with the bacterial TolC protein, which is involved in the development of multidrug resistance in pathogens. In this study, glutathione-coated AgNCs were synthesized and characterized. Their toxicological properties were studied in a microplate assay against five bacterial strains, both as single components and in mixtures with heavy metal salts and antibiotics. The resulting AgNCs had a diameter of 2.2 ± 0.5 nm, with excitation and emission maxima of λ = 490 nm and λ = 638 nm, respectively. No significant growth inhibition was observed at the concentrations used in res

SUBMITTER: Burygin GL 

PROVIDER: S-EPMC12787750 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature