Evaluation of Pyrrole Heterocyclic Derivatives as Selective MAO-B Inhibitors and Neuroprotectors.

ABSTRACT: Novel pyrrole-based derivatives were synthesized in high purity and yields (52-89%), with 17i and 17j displaying selective MAO-B inhibition (50-60%), comparable to Selegiline, and negligible MAO-A activity. In rat brain subcellular fractions, both compounds showed low intrinsic neurotoxicity at 100 μM while exerting significant neuroprotective and antioxidant effects under 6-OHDA, t-BuOOH, and Fe²⁺/ascorbate-induced stress. Mechanistic studies indicate dual protection via reactive oxygen species scavenging and preservation of reduced glutathione, with mitochondria and microsomes being the most responsive compartments. The performed in silico analysis revealed no general toxicity alerts, though hydrazine groups classify the compounds as contact allergens, and the fu

SUBMITTER: Georgieva M 

PROVIDER: S-EPMC12787771 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature