Nutritional Supplementation for Myopia Prevention and Control: A Systematic Review of Randomized Controlled Trials.

ABSTRACT:

Background/objectives

Nutritional supplementation has been proposed as a potential adjunct strategy in myopia prevention and control through antioxidative, anti-inflammatory, and extracellular matrix-regulating mechanisms. This systematic review aimed to evaluate randomized controlled trial (RCT) evidence on the effects of carotenoids, anthocyanins, polyunsaturated fatty acids, and combined nutraceutical formulations on refractive outcomes, axial length, macular pigment optical density (MPOD), visual function, and symptoms of visual fatigue.

Methods

The review was registered in PROSPERO (CRD420251149727) and conducted in accordance with PRISMA 2020 and AMSTAR-2 guidelines. PubMed, Web of Science, and Scopus were searched up to 5 August 2025. Eligible studies were RCTs involv

SUBMITTER: Martinez-Perez C 

PROVIDER: S-EPMC12787848 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature