The KLOTHO Birth Cohort: Maternal and Neonatal Vitamin D Status and Neurodevelopmental Outcomes at 10 Years.

ABSTRACT:

Background

Maternal vitamin D status during pregnancy has been hypothesized to influence offspring neurodevelopment; however, the evidence remains inconsistent.

Methods

We studied 66 mother-child pairs from the KLOTHO cohort with serum 25-hydroxyvitamin D [25(OH)D] measurements at delivery (maternal and umbilical cord). At 10 years of age, neurodevelopment was assessed using standardized questionnaires, generating composite z-scores for cognitive (cognitive, communication, motor) and psychosocial (social-sentimental, special interests) domains. Multivariable models were adjusted for sex, maternal body mass index and education, and neonatal birth weight and gestational age.

Results

Maternal 25(OH)D deficiency (<50 nmol/L) was not associated with cognitive compos

SUBMITTER: Karras SN 

PROVIDER: S-EPMC12787897 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature