Evaluating Polymer Characterization Methods to Establish a Quantitative Method of Compositional Analysis Using a Polyvinyl Alcohol (PVA)/Polyethylene Glycol (PEG)-Based Hydrogel for Biomedical Applications.

ABSTRACT: Multi-component polymer hydrogels present complex physiochemical interactions that make accurate compositional analysis challenging. This study evaluates three analytical techniques: Nuclear Magnetic Resonance (NMR), Advanced Polymer Chromatography (APC), and Thermogravimetric Analysis (TGA) to quantify polyvinyl alcohol (PVA) and polyethylene glycol (PEG) content in hybrid freeze-thaw derived PVA/PEG/PVP hydrogels. Hydrogels were synthesized using an adapted freeze-thaw method across a wide range of PVA:PEG ratios, with PVP included at 1 wt% to assess potential intermolecular effects. NMR and APC reliably quantified polymer content with low average errors of 2.77% and 2.01%, respectively, and were unaffected by phase separation or hydrogen bonding within the composite matrix. TGA enabled

SUBMITTER: Abbondandolo AG 

PROVIDER: S-EPMC12787944 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature