Dietary Choline Intake During Pregnancy and Congenital Heart Defects in a Chinese Population.

ABSTRACT: Background/Objectives: The impact of choline on congenital heart defects (CHDs) in humans remains unclear. This study aimed to investigate the associations between maternal dietary intakes of choline and choline derivatives during pregnancy and CHD. Methods: This case-control study included 474 cases and 948 controls from hospitals in Northwest China. Pregnant women admitted for delivery were enrolled and completed a validated food frequency questionnaire to assess their dietary intake during pregnancy. A standardized questionnaire was also administered to collect additional pregnancy-related information. Mixed logistic regression models were used to estimate ORs (95%CIs) for CHD in association with choline intake. Results: Higher intakes of total choline, phosphatidyl

SUBMITTER: Li YH 

PROVIDER: S-EPMC12788036 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature