Bioactive Surface Modifications on Bioresorbable Bone Screws: A Step Forward in Orthopedic Surgery.

ABSTRACT: Despite metals currently being widely used in orthopedic surgery, their mechanical properties significantly differ from the surrounding tissues and organs, causing low biocompatibility. Biodegradable, non-toxic, and non-immunogenic materials seem to be more convenient for clinical implementation. Our research was aimed at the construction of a polylactide screw covered with collagen, nanohydroxyapatite, and polylactide, with a variant including silver nanowires for antibacterial properties, as well as the analysis of their physico-chemical and biological properties. Adherent human osteosarcoma cells (2T line) were shown to grow on the porous surface layers. A cytotoxicity assay using WST1 revealed the non-toxic nature of the coatings and showed an increase in cell adhesion and proliferatio

SUBMITTER: Matveyeva AG 

PROVIDER: S-EPMC12788077 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature