Modulation of Peripheral Immune Cells Following Vitamin D₃ Supplementation in Vitamin D-Insufficient Cancer Patients.

ABSTRACT: Background and aims: Low vitamin D₃ levels are common in cancer patients, and these patients might benefit from vitamin D₃ level normalization in parallel with the conventional oncology treatment. This study aimed to examine the molecular effects of moderate-high-dose vitamin D₃ supplementation in vitamin D-deficient cancer patients. Methods: Eight patients under oncological treatment (5 lung cancer, 2 colorectal cancer, and 1 urothelial carcinoma) received 30,000 IU of vitamin D₃ per week for two months. Blood samples were collected before and after supplementation, and peripheral blood mononuclear cells (PBMCs) were isolated. With the aim of assessing further potential epigenetic alterations, global DNA methylation level was estim

SUBMITTER: Kalmar A 

PROVIDER: S-EPMC12788083 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature