Influence of APOE4 Genotypes on Nutrient-Cognition Relationship in Taiwanese Older Adults: Longitudinal Findings from the HALST.

ABSTRACT: Background: Older adults carrying the APOE4 allele are at elevated risk for cognitive decline. To clarify how dietary patterns may influence cognitive deterioration in this high-risk group, further investigation is needed. Methods: This prospective cohort study followed 1420 Taiwanese adults aged 65 years or older. Dietary intake was assessed using a validated food frequency questionnaire, and cognitive function was measured with the Mini-Mental State Examination (MMSE). Changes in 31 nutrients between two survey waves were used to simulate the effect of dietary shifts, and dietary patterns were derived using principal component analysis (PCA) with oblimin-derived scores. The analysis was further stratified by APOE genotype, and multiple linear regression models adjusted for

SUBMITTER: Lai RH 

PROVIDER: S-EPMC12788161 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature