Design, synthesis, biological evaluation, and <i>in silico</i> studies of novel 1,3-thiazole derivatives.

ABSTRACT: A series of novel 1,3-thiazole heterocyclic derivatives has been synthesized and structurally characterized using melting point, FT-IR, 1D and 2D NMR, and HR-MS. The compounds were screened for antibacterial activities, three human cancer cell lines (A549, HepG2, and MCF-7), and anti-inflammatory and α-glucosidase inhibitory activities, utilising MIC, MTT, α-glucosidase inhibitory, and NO assays, respectively. Entry 4e exhibited the most potent antibacterial activity (MIC = 83.5 µM). Entry 4g exhibited significant inhibitions against three cancer cell lines: MCF-7, HepG2, and A549 (IC₅₀ = 2.6-6.6 µM). Entry 4f exhibited significant anti-inflammatory activity (IC₅₀ = 15.4 ± 1.0 µM), comparable to the dexamethasone drug (IC₅₀ = 13.7 ± 1.2 µM). Notably, 4a and

SUBMITTER: Khanh ND 

PROVIDER: S-EPMC12788379 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature