Upregulation of angiotensin-(1-7) formation in human podocytes - enzyme activity assay upon fluid flow shear stress.

ABSTRACT: The renin-angiotensin system is known for its role in renal physiology by regulating renal hemodynamics and natriuresis. Overactivation of this system exerts pathological effects in the kidney, primarily mediated by its main effector peptide angiotensin II. Deleterious angiotensin II-mediated effects are counter-regulated at least partly by the biologically active renin-angiotensin system component angiotensin-(1-7). The processing of angiotensin II to angiotensin-(1-7) by prolylcarboxypeptidase, angiotensin converting enzyme 2, and prolyl endopeptidase is cell- and species-specific, with limited knowledge regarding its conversion in human podocytes under conditions of glomerular hyperfiltration. Since hyperfiltration plays a critical mechanistic role in albuminuria progression and chronic

SUBMITTER: Kaiser-Graf D 

PROVIDER: S-EPMC12788633 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature