Causal associations of specific immunoglobulin G N-glycosylation subtypes with osteoporosis: A two-sample Mendelian randomization.

ABSTRACT:

Objectives

This study aims to examine whether genetically predicted immunoglobulin G (IgG) N-glycosylation patterns (IGPs) affect osteoporosis risk using a two-sample Mendelian randomization (MR) method.

Materials and methods

In a collaborative effort involving the Medical Research Council (MRC) Human Genetics Unit and the FinnGen consortium, we conducted genome-wide association studies (GWAS) to explore the relationship between 77 IGPs (8,090 samples) and osteoporosis (438,872 samples). Utilizing the inverse-variance weighted (IVW) method as our primary analytical tool, we delved into these complex genetic associations. To further substantiate our findings, we employed additional complementary methods such as MR-Egger, weighted median, and weighted mode. Sensitivity analyse

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12788744 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature