Optimizing Postoperative Analgesia in Total Knee Arthroplasty: A Randomized Controlled Trial on the Efficacy of Perineural Dexamethasone With iPACK and Adductor Canal Block.

ABSTRACT:

Objectives

To assess the effect of perineural dexamethasone on analgesia duration and opioid consumption when used as an adjuvant to the iPACK (infiltration between the popliteal artery and capsule of the knee) block and adductor canal block in patients undergoing total knee arthroplasty.

Methods

In this double-blind, randomized controlled trial, 60 patients aged 65 years or older undergoing total knee arthroplasty under spinal anesthesia were assigned to one of 2 groups. The control group received iPACK and adductor canal block with 0.2% ropivacaine alone, while the Dexamethasone group received the same blocks with the addition of perineural dexamethasone. The primary outcome was time to first opioid rescue analgesia. Secondary outcomes included total opioid consumption ove

SUBMITTER: Reysner T 

PROVIDER: S-EPMC12788753 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature