Key regulatory roles of PRDM1 in human NK-cell differentiation and activation.

ABSTRACT: PRDM1, encoding a transcription factor (TF), regulates plasma cell and CD8⁺ T-cell terminal differentiation and T_h2 lineage specification, while its role in human NK-cell differentiation and homeostasis is largely unknown. Here, we employed a multi-omics approach to dissect the transcriptional control of PRDM1 on human NK-cells. PRDM1 is important in NK-cell terminal differentiation based on gene expression profiling and its targeting of key regulators in the process. PRDM1-deleted NK-cells displayed a less mature phenotype simulating the CD56^bright NK-cell population accompanied by upregulation of stem-like gene signatures. PRDM1-bound genes were enriched in T/NK-cell receptor signaling, activation, and NK-cell effector functions. PRDM1 could function as a

SUBMITTER: Liu X 

PROVIDER: S-EPMC12789010 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature