Role of common host genome variants in Childhood Acute Lymphoblastic Leukemia.

ABSTRACT: Childhood acute lymphoblastic leukemia (ALL) is a genetically heterogeneous disease, and while somatic alterations inform diagnosis and treatment stratification, germline variants - particularly common host genome variants - rarely influence clinical care. Over the past decade, various host genome variant studies have uncovered numerous common variants associated with ALL susceptibility, treatment efficacy, and toxicity risk. Yet, less than a handful have reached clinical implementation, with TPMT and NUDT15 variants being the only ones widely used clinically. Whether a variant can be readily translated into the clinical setting primarily depends on four features: (1) Phenotype severity, (2) phenotype rarity and the proportion of cases (overall or in subsets of patients) accounted for by g

SUBMITTER: Mikkelsen T 

PROVIDER: S-EPMC12789036 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature