Glial cells are involved in day-night protein dysregulation in the hippocampus of a mouse model of Alzheimer's disease.

ABSTRACT: The hippocampus regulates memory and cognition, both of which are influenced by circadian rhythms. These rhythms also drive time-dependent gene expression in neurons and glial cells, affecting hippocampal function. In Alzheimer's disease (AD), alterations in these rhythms, contributing to cognitive decline, is little understood. This study examined hippocampal proteomes from 7-month-old wild-type (WT) and 3xTgAD mice at two time points (Zeitgeber 2, ZT2 and ZT14) to detect early pathological changes. In WT mice, 199 proteins (8%) showed diurnal variation, particularly those linked to energy metabolism and neuronal/glial functions. In 3xTgAD mice, this rhythmic variation dropped by half (3.6%), with only five proteins shared across genotypes. Moreover, significant differences in protein exp

SUBMITTER: Badina AM 

PROVIDER: S-EPMC12789085 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature