Demographic, clinical and genetic characteristics of patients with amyotrophic lateral sclerosis from two specialised centres in Austria.

ABSTRACT:

Background

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by progressive muscle weakness and ultimately death from respiratory failure. Heterogeneity in disease trajectories and outcomes among patients with ALS (pwALS) is influenced by healthcare access, rehabilitation, and palliative care, but real-world data on demographic and clinical characteristics remain scarce in many countries, including Austria.

Objectives

To characterise the demographic, clinical, and genetic landscape of pwALS in Austria.

Methods

In this retrospective cohort study, we included pwALS diagnosed according to the Gold Coast criteria and treated at two large tertiary referral centres. Demographic, clinical, and genetic data were extracted from the local ALS reg

SUBMITTER: Keritam O 

PROVIDER: S-EPMC12789124 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature