Reactive oxygen species-sensitive release of cephalexin from hyaluronic acid-g-cephalexin dimer copolymer for treatment of inflammation and infection of oral soft tissue cells.

ABSTRACT: Since inflammation and/or infection against soft tissue cells increased oxidative stress and CD44 receptor expression, graft copolymer was synthesized using hyaluronic acid (HA) and cephalexin (CPX). To produce CPX dimer, to molecules of CPX were conjugated with carboxylic acid group of thioketal dicarboxylic acid (ThdCOOH). CPX dimer was conjugated with HA using thioketal diamine (ThdNH₂) to synthesize HA-g-CPX copolymer (Abbreviated as HAgCPX). Nanoparticles of HAgCPX copolymer was fabricated by dialysis method. They were assembled in the aqueous solution and formed spherical nanoparticles with small dimeter less than 300 nm. Since HAgCPX copolymers have ROS-sensitive linkage such as thioketal group, they were disintegrated in the presence of H₂O₂, partic

SUBMITTER: Kim CY 

PROVIDER: S-EPMC12789125 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature