Validity of hemoglobin A1C for screening prediabetes and diabetes in the Iranian population: analysis of National surveillance data.

ABSTRACT: Glycosylated hemoglobin (HbA1c) is a crucial biomarker in the diagnosis and management of dysglycemia. However, its diagnostic accuracy, especially considering its variations by age and sex, remains unclear. This study utilized data from Iran's 2016 Stepwise Approach to Surveillance Survey. A total of 18,729 individuals aged ≥ 25 years old without diabetes were analyzed. The validity of HbA1c for detecting prediabetes and diabetes was assessed using measures of concordance, the Kappa statistic, and the area under the curve (AUC), with fasting plasma glucose (FPG) as the reference. Additionally, optimal HbA1c thresholds for prediabetes and diabetes were determined. The AUCs of HbA1c for detecting diabetes were 0.96 (95% CI 0.95-0.97) in women and 0.94 (95% CI 0.92-0.96) in men. For prediabe

SUBMITTER: Talaschian M 

PROVIDER: S-EPMC12789137 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature