A large-scale multi-ancestry genome-wide association study of chronic prostatitis/chronic pelvic pain syndrome in men.

ABSTRACT: Chronic prostatitis/chronic pelvic pain syndrome is common, and it impacts men's health and quality of life. The genetic basis of this condition remains largely unknown. Here, we conduct a GWAS using data from the Million Veteran Program of over 590,000 men of European, African, and Hispanic ancestry, including 14,575 chronic prostatitis/chronic pelvic pain syndrome cases. The multi-ancestry analysis identifies eight novel loci associated with chronic prostatitis/chronic pelvic pain syndrome risk, an increase from three significant genome-wide loci found in the European participants alone. We also estimate the genetic correlations between chronic prostatitis/chronic pelvic pain syndrome and 12 phenotypes. Notably, the genetic correlation between chronic prostatitis/chronic pelvic pain synd

SUBMITTER: Rosenthal SB 

PROVIDER: S-EPMC12789528 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature