Automated cardiac MRI analysis for robust profiling of heart failure models in mice.

ABSTRACT: Heart failure with preserved ejection fraction (HFpEF) is a complex, age-related cardiovascular disease with limited treatment options, partly due to a poor understanding of underlying mechanisms, lack of robust preclinical models and diagnostic tools with limited specificity. Traditional cardiac magnetic resonance imaging (MRI) protocols and analysis in preclinical research are time-consuming, and manual analysis methods are prone to high inter-observer variability (correlation coefficient of 0.79 for left ventricular (LV) ejection fraction between observers). To accelerate and standardize phenotyping, we optimized a comprehensive non-contrast cardiac MRI protocol for high throughput, enabling acquisition of a stack of 12 short-axis slices in approximately seven minutes. This time-efficie

SUBMITTER: Yoganathan T 

PROVIDER: S-EPMC12789537 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature