Unveiling the toxic effects of perfluorooctanoic acid on osteoblast function and extracellular matrix deposition using 2D and 3D models.

ABSTRACT: Emerging evidence revealed an association between perfluorooctanoic acid (PFOA) exposure and reduced bone mass density, leading to osteoporosis disease. This confirms the bone as a target tissue for per- and polyfluoroalkyl substances (PFAS). However, it is still unclear during which phase, proliferation or differentiation, PFOA exerts the most significant harm on osteoblasts, the cells responsible for secreting bone matrix. To tackle the intriguing question of how PFOA treatment affects the process, this study investigated the impact of different concentrations of PFOA on 2D and 3D human fetal osteoblast (hFOB1.19) cell line cultures representing the proliferation and differentiation phases, respectively. In 2D cultures, a 6-day PFOA exposure impaired antioxidant defense without directly

SUBMITTER: Sella F 

PROVIDER: S-EPMC12789562 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature