Regulation of tumor hypoxic microenvironment by cyanobacteria-photosensitizer hybrid bioplatform for enhanced photodynamic therapy.

ABSTRACT: Tumor hypoxic microenvironments limit the generation efficiency of reactive oxygen species (ROS) in photodynamic therapy (PDT) and exacerbate immune suppression, severely restricting its clinical efficacy. To overcome this bottleneck, this study developed a bio-organic hybrid delivery system based on oxygen-producing cyanobacteria and nano-photosensitizers (PCC7942@ICG-NPs), which synergistically enhances efficacy through in situ oxygen delivery and augment ROS. Specifically, indocyanine green (ICG) was loaded onto bovine serum albumin (BSA) via hydrophobic interactions to form stable nanoparticles (ICG-NPs), and the positively charged surface of the nanoparticles enabled efficient self-assembly with the oxygen-producing cyanobacterium PCC7942 by electrostatic interactions. Upon near-infra

SUBMITTER: Sun M 

PROVIDER: S-EPMC12789613 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature