Hematologic and solid-organ malignancy risk in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

ABSTRACT:

Background

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease characterized by small- and medium-vessel inflammation. Although chronic immune dysregulation and cytotoxic therapy exposure have been hypothesized to increase malignancy risk, large-scale, real-world evidence quantifying these risks has been limited. This study aimed to characterize hematologic and solid-organ malignancy risk profiles in patients with AAV using a large, multi-institutional database.

Methods

We conducted a retrospective cohort study using the TriNetX Research Network, using de-identified electronic medical record data from 2014 to 2024. We identified 19,238 patients with AAV and performed 1:1 propensity score matching to seborrheic keratosis control

SUBMITTER: Mahajan A 

PROVIDER: S-EPMC12789623 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature