Frailty in Patients With Hematologic Malignancies and Patients Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review.

ABSTRACT:

Background

Hematopoietic stem cell transplantation (HSCT) is associated with significant morbidity and mortality. Frailty further increases these risks in recipients of HSCT. This systematic review analyzes the extent of frailty in patients with hematologic malignancies and patients undergoing HSCT, and explores the associations between frailty and age, and clinical outcomes.

Methods

CINAHL (EBSCO), Embase (Ovid), and Medline were searched for quantitative studies including assessment tools aimed at identifying frailty or vulnerability. Two reviewers independently assessed eligibility, extracted data from the included articles, performed a quality appraisal, and analyzed the findings through narrative synthesis.

Results

Of the 5190 abstracts screened, 17 articles invo

SUBMITTER: Bakken M 

PROVIDER: S-EPMC12789654 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature