Mycobacterial respiratory chain enzymes and growth are inhibited by decylubiquinone.

ABSTRACT: Aerobic organisms obtain energy by linking electron transfer from NADH to O₂, through the respiratory chain, to transmembrane proton translocation. In mycobacteria the respiratory chain is branched; the membrane-bound electron carrier menaquinol (MQH₂) donates electrons either to the O₂-reducing cytochrome bd or a supercomplex that is composed of a complex (C) III₂ dimer flanked by two CIVs. Here, we measured the dimethyl-naphthoquinone (DMNQH_2, a menaquinol analogue) oxidation:O₂ reduction activities of the CIII₂CIV₂ supercomplex and cytochrome bd in the presence of an analogue (decylubiquinone, DCQ) of the mammalian electron carrier, ubiquinol. The data show that DCQH₂ inhibits both the CII

SUBMITTER: Krol S 

PROVIDER: S-EPMC12789660 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature