Fermented Rice Bran: A Promising Therapeutic Agent Against High-Fat Diet-Induced Metabolic Disorders.

ABSTRACT: The increasing consumption of a high-fat diet (HFD) triggers metabolic diseases such as obesity, diabetes, dyslipidemia, and MAFLD (metabolic dysfunction-associated fatty liver diseases). This situation demands natural and healthy therapeutic diets. Rice bran is a widely available, nutrient-dense by-product of rice. This study aimed to explore the compositional profile of optimized solid-phase fermented rice bran (FRB) and nonfermented rice bran (NFRB) and, subsequently, its effect on HFD-induced obese rats. We found that the fermentation process improved the nutritional quality and antioxidant properties of rice bran, and FRB supplementation (8 weeks) decreased body weight gain by 3.5%, blood glucose levels by 2.03 mmol/L, and liver fat. However, FRB administration improved cognitive func

SUBMITTER: Sultana A 

PROVIDER: S-EPMC12789662 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature