Network pharmacology and in vitro studies demonstrate modulation of fibrotic pathways by Swertia chirayita in pulmonary fibrosis.

ABSTRACT: Various biological processes contribute to pulmonary fibrosis, which results in fibrotic foci that impede the exchange of gases between alveoli and capillaries. This study investigates the therapeutic mechanism in fibrotic foci reconfiguring via the TNF signaling pathway by potential Swertia chirayita (SC) components to treat pulmonary fibrosis by network pharmacology, in silico, and in vitro studies. The targets of LC-MS/MS analyzed SC components were used to build a protein-protein interaction network in Cytoscape and predicted key targets and signalings. The molecular docking, dynamics (MD) simulation, and principal component analysis (PCA) were performed to predict the potential interactions between components and their targets. In vitro studies, such as cell migration, E-cadherin immu

SUBMITTER: H B B 

PROVIDER: S-EPMC12789668 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature