Steroid hormone biosynthesis and dietary related metabolites associated with excessive daytime sleepiness.

ABSTRACT:

Background

Excessive daytime sleepiness (EDS) is a complex sleep problem that affects approximately 33% of the United States population. Although EDS usually occurs in conjunction with insufficient sleep and other sleep and circadian disorders, recent studies have shown unique genetic markers and metabolic pathways underlying EDS. Here, we aimed to further elucidate the biological profile of EDS using large-scale single- and pathway-level metabolomics analyses.

Methods

Metabolomics data were available for 877 metabolites in 6071 individuals from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). EDS was assessed using the Epworth Sleepiness Scale (ESS) questionnaire. We performed linear regression for each metabolite on the continuous ESS score, adjusting for d

SUBMITTER: Faquih T 

PROVIDER: S-EPMC12789706 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature