Sex-stratified metabolic signatures of adiposity indices and their associations with clinical biomarkers in the UK Biobank.

ABSTRACT:

Background

Excessive adiposity increases disease risk, however, the metabolic processes underlying these associations remain incompletely understood.

Methods

We compared metabolic signatures (MSs) of adiposity indices (non-allometric: body fat %, waist circumference, hip circumference, waist-to-hip ratio, body mass index; allometric: a body shape index [ABSI], hip index [HI], waist-to-HI ratio) by sex and examined their cross-sectional associations with 29 clinical biomarkers in 151,526 UK Biobank participants. MSs performance was validated in an independent cohort.

Findings

In females, MSs mainly consisted of lipoprotein particle concentrations, apolipoproteins, fatty acids and inflammation-linked glycoprotein acetyls, whereas in males lipoproteins rich in cholestery

SUBMITTER: Papagiannopoulos CK 

PROVIDER: S-EPMC12789707 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature