Gut microbiota regulates exercise-induced hormetic modulation of cognitive function.

ABSTRACT:

Background

Lifestyle factors, particularly physical exercise, significantly influence brain structure and cognitive function through a hormetic effect -a phenomenon where low to moderate doses of a stimulus (in this case, exercise) induce beneficial adaptations, while excessive doses could lead to detrimental effects. This effect depends on exercise intensity and duration, though the underlying mechanisms remain largely unexplored. Recently, the gut microbiota has emerged as potent modulator of lifestyle-induced changes in brain and behaviour.

Methods

We used a 40-min, 1200 cm/min exercise protocol. We measured cognition through several tests and analysed microbiota composition comparing adult exercised animals to sedentary controls. Finally, we performed fecal microbiota tr

SUBMITTER: Cintado E 

PROVIDER: S-EPMC12789708 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature