Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway.

ABSTRACT:

Introduction

Kaempferol (KAE) is a flavonoid found in various plants. Recent studies showed that high dietary intake of KAE was associated with a lower risk of myocardial infarction; however, the cardioprotective mechanism of KAE remains unknown.

Objectives

To determine the effect of KAE on cardiac injury in isoproterenol (ISO)-induced rats and cobalt chloride (CoCl₂)-treated cardiomyocytes, and the underlying mechanisms.

Methods

Male rats were pretreated with different doses of KAE for 14 days, and then injected with ISO to induce myocardial ischemia injury. We also established a model of myocardial cell injury using rat H9c2 cardiomyocytes stimulated with CoCl₂.

Results

We found that KAE pretreatment significantly alleviated myocardial i

SUBMITTER: Yue Z 

PROVIDER: S-EPMC12789718 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature