Neural and molecular investigation into the paraventricular thalamus for chronic restraint stress induced depressive-like behaviors.

ABSTRACT:

Introduction

Disturbance of neural circuits and chronic stress contribute to depression onset. Given the crucial role of paraventricular nucleus of thalamus (PVT) in emotional behaviors, however, the specific neural and molecular mechanism of PVT in depression still unclear.

Objective

Our study aim to explore the neural and molecular mechanism of PVT in depression.

Methods

In the present study, we utilize behavioral tests,chemogenetics, RNA-sequence, molecular profiling and pharmacological approaches to investigate the role of PVT in depression.

Results

We observed that CamkIIα neurons in PVT were inactivated by chronic restraint stress (CRS) with reduced c-Fos positive neurons. Activation of PVT^CamkIIα neurons displayed antidepressant-like effect in

SUBMITTER: He Y 

PROVIDER: S-EPMC12789719 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature