Pleiotropic role of CCR9/CCL25 signaling in adriamycin-induced cardiomyopathy.

ABSTRACT:

Introduction

Adriamycin (ADR)-induced cardiomyopathy is a common problem in many cancer survivors. Recently, specific chemokine receptors have garnered interest as therapeutic targets in cardiovascular diseases.

Objectives

This study aim to report the role of C-C chemokine receptor 9 (CCR9)/C-C chemokine ligand 25 (CCL25) and its therapeutic potential in ADR-induced cardiomyopathy.

Methods

Functional gene knockout and overexpression mouse models were utilized to investigate the role of CCR9 against ADR-induced cardiomyopathy. Transcriptome sequencing was also performed to identify the downstream molecular mechanisms of CCR9.

Results

This study revealed that CCR9 and CCL25 levels were increased in mice and HL-1 cells injured by ADR, consistent with the results o

SUBMITTER: Wu X 

PROVIDER: S-EPMC12789724 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature