Genetic associations of metabolic factors and therapeutic drug targets with polycystic ovary syndrome.

ABSTRACT:

Introduction

Polycystic ovary syndrome (PCOS) is frequently accompanied with metabolic dysfunctions, yet the causal relationships between metabolic factors and PCOS remain to be conclusively established and etiology-based therapies are lacking.

Objectives

To comprehensively identify the metabolic causal factors and potential drug targets for PCOS.

Methods

This genetic association study was conducted using bidirectional two-sample Mendelian Randomization (MR), multivariable MR (MVMR) and drug-target MR. Considering metabolic sexual dimorphism, female-specific genome-wide association studies (GWASs) for metabolic factors were obtained. To ensure the robustness of the findings, an additional independent PCOS GWAS dataset was utilized for replication.

Results

The P

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12789731 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature