Achilles tendinopathy treatment via circadian rhythm regulation.

ABSTRACT:

Introduction

Achilles tendinopathy (AT) is a prevalent musculoskeletal disorder closely linked to oxidative stress. Existing evidence suggests a potential link between circadian clock rhythms and oxidative stress. However, the precise role of the circadian clock in the progression and treatment of AT remains unclear.

Objective

The purpose of this study was to investigate the role of the Achilles tendon circadian clock in AT pathology and explore the potential use of biomaterials for modulating the circadian clock in the treatment of AT.

Methods

We utilized in vivo and in vitro models to investigate the alterations of the circadian clock within the Achilles tendon during the progression of AT, as well as its impact on disease development. Additionally, we fabricated Nb

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12789736 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature