Chromosome-scale assembly with improved annotation provides insights into breed-wide genomic structure and diversity in domestic cats.

ABSTRACT:

Introduction

Comprehensive genomic resources offer insights into biological features, including traits/disease-related genetic loci. The current reference genome assembly for the domestic cat (Felis catus), Felis_Catus_9.0 (felCat9), derived from sequences of the Abyssinian cat, may inadequately represent the general cat population, limiting the extent of deducible genetic variations.

Objectives

The goal was to develop Anicom American Shorthair 1.0 (AnAms1.0), a reference-grade chromosome-scale cat genome assembly.

Methods

In contrast to prior assemblies relying on Abyssinian cat sequences, AnAms1.0 was constructed from the sequences of more popular American Shorthair breed, which is related to more breeds than the Abyssinian cat. By combining advanced genomics techno

SUBMITTER: Matsumoto Y 

PROVIDER: S-EPMC12789764 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature