2'-Fucosyllactose ameliorates aging-related osteoporosis by restoring gut microbial and innate immune homeostasis.

ABSTRACT:

Introduction

Aging-related osteoporosis is considered as a serious public health concern for middle-aged and elderly people, with an intricated pathogenesis including the recently identified aging-induced immunological dysfunction and gut microbial disorder. The intervention based on dietary prebiotics is recommended to retain bone health and postpone the progression of osteoporosis.

Objectives

As a well-defined prebiotic, 2'-fucosyllactose (2'-FL) has been thoroughly validated with positive effect on systemic health and was proposed in this study to unveil its intervention on aging-related osteoporosis, as well as the underlying mechanisms involving the gut microecology and innate immunity.

Methods

The effects of dietary 2'-FL on osteoporosis phenotypes were identifi

SUBMITTER: Li A 

PROVIDER: S-EPMC12789774 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature