DNA methylation profiles aid to identify putative genome activation histories along lymphomagenesis.

ABSTRACT: DNA methylation (DNAm) is widely used to leverage biological information in the context of cancer. Active regulatory elements marked by increased chromatin accessibility and specific transcription factor (TF) binding, such as enhancers, show tumor-specific DNAm patterns reflecting the biological forces shaping tumorigenesis. However, DNAm changes also occur at regions that are inactive at histone-mark level in fully developed tumors. Beyond hypermethylation of promoters, these changes are often overlooked, leaving their functional relevance poorly understood. By analyzing DNAm and chromatin state annotations from conventional mantle cell lymphoma (cMCL), we identified a subset of ~300 CpGs with homogeneous cMCL-specific demethylation patterns located in cMCL-inactive regions. We show that

SUBMITTER: Albinati L 

PROVIDER: S-EPMC12789802 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature