DERL3 exacerbates glioblastoma malignancy through endoplasmic reticulum stress-dependent mechanisms.

ABSTRACT: Gliomas, particularly glioblastoma multiforme (GBM), represent the most prevalent primary intracranial malignancies, characterized by high invasiveness, aggressive proliferation, and poor clinical outcomes. Recent studies have highlighted the critical role of tumor microenvironment interactions and cellular stress responses, including endoplasmic reticulum (ER) stress, in modulating glioma progression. While ER stress can induce autophagy and apoptosis, glioma cells exhibit remarkable plasticity, adapting to stress conditions and exploiting them to promote survival and self-renewal, thereby contributing to therapeutic resistance. In this study, we established an individualized ER stress risk score using glioma transcriptomic data, demonstrating its association with adverse prognosis, aggre

SUBMITTER: Du S 

PROVIDER: S-EPMC12789912 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature