Body Composition Changes After Bariatric Surgery or Treatment With GLP-1 Receptor Agonists.

ABSTRACT:

Importance

The association of bariatric surgery and newer glucagon-like peptide-1 receptor agonists (GLP-1RAs; semaglutide and tirzepatide) with body composition still lack evidence from clinical settings.

Objective

To examine temporal changes in fat-free mass (FFM), fat mass (FM), and FFM to FM ratio after bariatric surgery or GLP-1RA treatment over 24 months.

Design, setting, and participants

This retrospective cohort study used electronic health records from Vanderbilt University Medical Center of 1257 patients aged 18 to 65 years who underwent first-time bariatric surgery from November 21, 2017, to July 21, 2022, without GLP-1RA treatment from 1 year before to 2 years after surgery, and 1809 nonsurgical patients who started semaglutide or tirzepatide between Novem

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12789952 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature