South Asian Representation in Cardiovascular Disease Randomized Controlled Trials: A Systematic Review.

ABSTRACT:

Background

One in 4 individuals worldwide is of South Asian ancestry and is therefore at increased risk for cardiovascular disease (CVD). However, South Asian representation in CVD randomized controlled trials (RCTs) is not well known.

Objectives

The aim of this systematic review was to measure South Asian representation in CVD RCTs and extract post-randomization primary outcome estimates for this population.

Methods

We conducted a systematic review to identify major CVD RCTs published between 2018 and 2022. Each study was manually screened and reviewed to identify South Asian participants and representation rates. The protocol for this systematic review was prospectively registered in PROSPERO (South Asian Representation in Cardiovascular Clinical Trials; CRD42023396

SUBMITTER: Uppal N 

PROVIDER: S-EPMC12790039 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature