Monitoring diaphragmatic effort during diaphragm neurostimulation-assisted ventilation.

ABSTRACT:

Rationale

Diaphragm neurostimulation-assisted ventilation (DNAV) can improve cardiopulmonary function during passive mechanical ventilation. However, this technique requires a reliable method to monitor and titrate diaphragmatic loading to avoid both insufficient and excessive diaphragmatic stimulation.

Objective

To establish whether the reduction in airway pressure-time product (ΔPTPaw) obtained during diaphragm neurostimulation in assist control volume-controlled mode accurately quantifies the magnitude of respiratory muscle effort elicited by neurostimulation.

Methods

This was a secondary analysis of the STIMULUS trial. Diaphragm neurostimulation was titrated across four levels targeting progressive occlusion pressures of 0, - 5, - 10, and - 15 cm H₂O at two PEEP l

SUBMITTER: Castellvi-Font A 

PROVIDER: S-EPMC12790116 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature