Risk factors for mortality in children with hypoxemia in resource-constrained settings: a secondary analysis of Global Paediatric Acute Critical Illness Point Prevalence Study (PARITY).

ABSTRACT:

Background

Hypoxemia, a mortality predictor and hallmark of pediatric acute respiratory distress syndrome (PARDS), is disproportionately common in resource-constrained settings (RCS). The burden of PARDS in RCS is likely substantial considering the high prevalence of known clinical triggers (e.g., sepsis, pneumonia, trauma), but it is challenging to diagnose due to limited diagnostic resources. We aimed to: (1) describe respiratory care resource availability in RCS hospitals and test whether availability was associated with mortality; (2) determine the proportion of children who presented to RCS hospitals with hypoxemia and their associated outcomes; and (3) test whether, in children with hypoxemia, having a PARDS trigger was associated with mortality.

Methods

We developed a

SUBMITTER: Biewen C 

PROVIDER: S-EPMC12790117 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature