Altered Dynamic Functional Network Connectivity in Post-Stroke Aphasia.

ABSTRACT:

Objective

Previous studies examining post-stroke aphasia (PSA) patients via resting-state functional magnetic resonance imaging (rs-fMRI) have predominantly focused on static functional connectivity. In contrast, the current investigation aims to elucidate the alterations in dynamic functional network connectivity (dFNC) among PSA patients.

Methods

We recruited 40 PSA patients and 41 age-, gender-, and education-matched normal controls (NCs). The participants underwent rs-fMRI and the Western Aphasia Battery (WAB) test. Independent component analysis (ICA) was used to identify resting-state networks (RSNs), and dFNC was constructed using a sliding window technique followed by k-means clustering to classify distinct dynamic network states. We compared the dFNC differences bet

SUBMITTER: Xu G 

PROVIDER: S-EPMC12790175 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature