Crohn's and bones: assessing bone microarchitecture using high-resolution peripheral quantitative computed tomography.

ABSTRACT: Crohn's disease (CD) is known to negatively affect BMD and inflammatory (non-stricture) and stricturing CD are the two common phenotypes. Studies exploring CD phenotypes with advanced imaging techniques, such as HR-pQCT, are lacking. Therefore, the aim of this cross-sectional study was to examine differences in bone quality, including volumetric BMD, bone microarchitecture, bone geometry, estimated bone strength, and void spaces, between inflammatory and stricturing CD phenotypes using HR-pQCT. Participants aged 55 yr and over were recruited and scanned by HR-pQCT (XtremeCT II) at the distal radius and tibia. Finite element analysis estimated bone strength and void space analysis captured structural inhomogeneities in the trabecular compartment. Health history and CD-specific information w

SUBMITTER: Klassen RE 

PROVIDER: S-EPMC12790273 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature