Myeloperoxidase Luminol Reaction - A Novel Faecal Assay for Predicting Colonoscopy Findings in Patients with Ulcerative Colitis: A Pilot Cross-Sectional Clinical Study.

ABSTRACT: Inflammatory Bowel Disease (IBD), including ulcerative colitis (UC), requires non-invasive, convenient and cost-effective biomarkers for disease monitoring. Myeloperoxidase (MPO), a neutrophil-derived enzyme, correlates with intestinal inflammation. This study aims to assess the Myeloperoxidase Luminol Reaction (MPOLR) assay - a novel chemiluminescent-based method for detecting faecal MPO (fMPO) activity, to improve the prediction of endoscopic findings in UC. A cross-sectional clinical study recruited 39 participants, categorized into UC (n = 20), colonoscopy control (CC; n = 9), and healthy control (HC; n = 10). Faecal samples are analysed for fMPO, calprotectin (fCalpro), and lactoferrin (fLacto) using ELISA and the MPOLR assay. The MPOLR assay is validated against endoscopic disease se

SUBMITTER: Kariyawasam V 

PROVIDER: S-EPMC12790305 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature