Natural-Based Nanocomposite Ink Engineering for Seamless Multi-Material Integration in Extrusion-Based 3D Printing.

ABSTRACT: Multi-tissue regeneration remains a critical clinical challenge due to the lack of solutions that can replicate the hierarchical heterogeneity of such complex interfaces. While biofabrication approaches, such as extrusion-based, allow replicating robust, biomimetic, and layered designs, constructs are usually hindered by inadequate phase/layer integration, poor filler dispersion, and mismatched rheological and mechanical performances. This study introduces an ink engineering strategy as a solution for integrating natural-based nanocomposites in multi-tissue regenerative approaches. For that, two photocrosslinkable natural matrices: a protein-bovine serum albumin methacrylate (BSAMA), and a polysaccharide-hyaluronic acid methacrylate (HAMA)-are selected for their complementary mechanical an

SUBMITTER: Maia JR 

PROVIDER: S-EPMC12790321 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature