Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death.

ABSTRACT: The primary driver of type I diabetes is the autoimmune T cells that destroy insulin-producing β-cells within the islets of Langerhans in the pancreas¹. Pancreatic islet macrophages have also been variably linked to disease onset and progression. As macrophage-mediated removal of dying cells through efferocytosis regulates tissue homeostasis and immune responses², here we investigated how efferocytosis by intra-islet macrophages influences the immune environment of pancreatic islets. Using a series of complementary omics-based and functional approaches, we identify a subset of anti-inflammatory intra-islet efferocytic macrophages (e-Mac) within the pancreas of mice and humans. When limited β-cell apoptosis is induced in vivo in wild-type C57BL/6 mice and diabetic-pron

SUBMITTER: Zakharov PN 

PROVIDER: S-EPMC12790336 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature