Characterisation of the N-Methyltransferase SgPsmC: Application in the Kinetic Resolution of Pyrroloindolines.

ABSTRACT: Many natural products and pharmaceutical compounds bear the pyrroloindoline scaffold, highlighting the importance of the heterocyclic motif. Here, we aim at expanding the toolset for the selective synthesis of pyrroloindolines by characterising and employing the N-methyltransferase SgPsmC from Streptomyces griseofuscus, an enzyme involved in the biosynthesis of physostigmine, in a selective kinetic resolution of pyrroloindolines performed at a laboratory preparative scale.

SUBMITTER: Chapple BP 

PROVIDER: S-EPMC12790363 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature